Vascularity and Dynamic Contrast-Enhanced Breast Magnetic Resonance Imaging

Angiogenesis is a key step in the initiation and progression of an invasive breast cancer. High microvessel density by morphological characterization predicts metastasis poor survival women with cancers. However, morphologic subject to variability only can evaluate limited portion Consequently, Magnetic Resonance Imaging (MRI) currently being evaluated assess vascularity. Recently, through new field radiomics, dynamic contrast enhanced (DCE)-MRI used vascular density, morphology, detection aggressive cancer biology. While DCE-MRI highly sensitive tool, there are specific features that limit computational evaluation blood vessels. These include (1) evaluates gadolinium does not directly biology, (2) resolution insufficient for imaging small vessels, (3) images very difficult co-register. Here we review approaches analysis vessels present some strategies have developed co-registry early vascularization.